Sr. Research Associate – In vivo Immuno-Oncology

Key Responsibilities:

At Constellation Pharmaceuticals we are pushing the boundaries of our understanding of how epigenetic mechanisms control transcription in health and disease, and by so doing, we are discovering novel treatments for immune-mediated diseases and cancer. We now have an exciting opportunity for an Sr. Research Associate who will be supporting in vivo mouse studies. The successful candidate will be responsible for all in vivo studies testing a diversity of therapeutic compounds as single agents or in combination in mouse syngeneic and xenograft models for immuno-oncology drug and biomarker discovery, as well as patient selection strategies. She/He will independently perform tumor cell inoculations, administration of therapeutic agents via multiple routes, tumor measurements, survival and overall animal health monitoring, tissue collection, and data recording. Depending on the candidate’s experience and qualifications, laboratory responsibilities could expand to ex vivo immune cell analyses and/or PK/PD biomarker analyses and offer opportunity for growth. The candidate will need to coordinate activities with project team members and should therefore possess excellent communication and organizational skills.

• Conduct exploratory and pre-clinical PK, PD and efficacy studies
• Preparation of test articles and tumor cells for in vivo administration via multiple routes
• Sub-cutaneous tumor cell inoculation and iv infusion of primary cells
• In vivo dosing of mice via various routes (ip, iv, sc and po)
• Tumor growth measurements
• Tissue harvesting (blood, tumor, lymph nodes, spleen, etc.)
• Routine monitoring for health
• Accurate documentation and outstanding data recording

Qualifications and Required Experience:

• Minimum 2-4 years of directly relevant lab experience in an academic or industry setting
• Exceptional in vivo experimental skills
• Extensive experience with mouse syngeneic and xenograft tumor models, i.e., tumor cell inoculation, mouse dosing, tissue harvesting, tumor measurements
• Proficiency in lab animal welfare and ability to precisely follow institutional procedures and protocols
• Overall knowledge and strict compliance with federal and institutional guidelines for animal care and use
• Strong attention to detail, excellent record keeping and organizational skills
• Proficiency with Microsoft Office
• Flexibility in working schedule to accommodate some evening and weekend work
• Ability to work both independently and with multiple collaborative teams
• Excellent communication and interpersonal skills
• AALAS or LAT certification is preferred
• Experience with tumor tissue processing and isolation of tumor-infiltrating immune cells is highly desired
• Experience with immune cell phenotyping by flow cytometry is a plus
• Experience with minimally invasive surgical procedures is preferred


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Constellation Pharmaceuticals is an Equal Opportunity Employer, a participant in E-Verify and offers a comprehensive benefits package, including health, dental, 401(k), paid vacation, tuition reimbursement, and much more.

We are not accepting unsolicited resumes from employment agencies for any employment opportunities at this time.

Constellation Pharmaceuticals, Inc.
215 First Street, Suite 200
Cambridge, MA 02142

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