Scientist/Sr. Scientist – Functional Genomics

The Functional Genomics group at Constellation seeks a highly motivated and enthusiastic Scientist or Senior Scientist to be a part of an integrated computational/experimental biology team that addresses key questions in chromatin biology, oncology, and immuno-oncology.  Individuals with experience in genetic manipulation/genome editing and an interest in exploring novel functional genomic technologies are desirable.  The position requires the ability to succeed in a dynamic, goal-oriented and highly collaborative environment.


Responsibilities include, but are not limited to:

  • Assimilating genomic, transcriptomic, and epigenomic data to generate testable hypotheses
  • Designing and executing genetic perturbation or genome editing studies to validate the function of target genes or gene control elements
  • Exploring the dynamic chromatin and transcriptional events downstream of target inhibition through the use of single cell profiling
  • Evaluating and triaging novel omics-based techniques for internalization by the group
  • Working across functional groups to support studies in translational and discovery biology
  • Communicating data to broad scientific audiences at internal meetings and external conferences



  • Ph.D. in life sciences with emphasis on cell or molecular biology with 3-5 years of post-doctoral or industry experience.
  • Deep knowledge and laboratory research experience in cancer signaling and transcriptional networks as demonstrated by peer-reviewed publications
  • Direct experience with genetic perturbation techniques, including CRISPR/Cas9, RNAi, and overexpression
  • Experience with analyzing and visualizing omics datasets using common bioinformatics tools
  • Ability to work independently in planning, executing and interpreting data and to execute projects in parallel
  • Flexibility to work in a multidisciplinary team environment and to interact across functional groups
  • Understanding of current scientific literature and willingness to explore new areas
  • Strong oral and written communication skills


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Constellation Pharmaceuticals is an Equal Opportunity Employer, a participant in E-Verify and offers a comprehensive benefits package, including health, dental, 401(k), paid vacation, tuition reimbursement, and much more.

We are not accepting unsolicited resumes from employment agencies for any employment opportunities at this time.