Scientist I/II | Discovery Biology

We are seeking a highly motivated Scientist I/II to join our team to perform experiments using cellular and molecular immunological assays to interrogate target biology, therapeutic mechanisms of action of lead compounds, and to support I-O biomarker discovery efforts. The successful candidate will work as part of Constellation’s Immuno-Oncology team to support the expansion of our immuno-epigenetic discovery programs and preclinical/clinical pipelines.  We are #BrighterTogether.

Title to be based upon qualifications.

How you will spend your day:

  • Working independently, creatively and collaboratively to determine methods and procedures, design and execute experiments to characterize the mechanism of action and the effects of small molecule drug candidates on the in vitro and in vivo modulation of immune function and antitumor immunity
  • As a member of drug discovery cross-functional teams, you will provide technical support for I-O target validation and biomarker discovery studies. Set-up and validate new ex vivo and in vivo disease models, and cell-based assays within a project scope
  • Acquiring/analyzing data, report/interpret the data and troubleshoot for problems in experiments. Present study results at group meetings. Track and report study progress and status with oversight from supervisor and/or project leader
  • Preparing technical reports, SOPs and experimental protocols
  • Providing project working groups with technical advice and problem troubleshooting related to methods, procedures, instrumentation issues, and suggest process changes to meet objectives
  • Interacting daily with supervisor and project leader to ensure that the most efficient experimental strategies are being employed
  • Maintaining high level of professional expertise through familiarity with scientific literature and present results at scientific meetings


Key things about you:

  • A PhD degree in immunology or closely related scientific discipline with a minimum of 5 years of relevant laboratory experience
  • 3+ years of post-doctoral research experience in immunology and/or oncology
  • Ideally, you will have spent some time applying your knowledge in an industry setting
  • A passion and proficiency in in vitro and ex vivo phenotypical/functional immune cell-based assays and anti-cancer drug screens
  • Experience in human and mouse immunology, including familiarity with I-O animal models and hands-on experience in multiparameter flow cytometry, ex vivo primary/immune cell isolation and culture, tumor-infiltrating lymphocyte profiling, ELISpot, Treg/Th/DC/CTL generation and tumor lysis assays
  • Expertise in T cell, dendritic cell, and macrophage biology is highly preferred
  • Experience with MS Office and data analysis software such as FlowJo and GraphPad Prism (knowledge of tSNE analysis and Spotfire is a plus)
  • Prior experience with any of the following assays is preferred: reporter, multiplex, and transcription assays, PDX models, human blood and tumor tissue/tumor cell implant processing, CRIPSR/Cas9-based gene editing in primary immune cells
  • Experience working and communicating in cross-functional/matrix teams and in a volume project/deadline-driven environment
  • Motivation and ability to demonstrate good leadership and teamwork skills while taking direction from supervisor


JOB CODE: Biology

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Constellation Pharmaceuticals is an Equal Opportunity Employer, a participant in E-Verify and offers a comprehensive benefits package, including health, dental, 401(k), paid vacation, tuition reimbursement, and much more.

We are not accepting unsolicited resumes from employment agencies for any employment opportunities at this time.