Research Associate/Sr. Research Associate

At Constellation Pharmaceuticals we are pushing the boundaries of our understanding of how epigenetic mechanisms control transcription in health and disease, and by so doing, we are discovering novel treatments for immune-mediated diseases and cancer. We now have an exciting opportunity for a (Sr.) Research Associate who will be supporting in vivo and in vitro studies in the area of immuno-oncology. You will be responsible for all in vivo studies testing a diversity of therapeutic compounds as single agents or in combination in mouse syngeneic and xenograft models for immuno-oncology drug and biomarker discovery, as well as patient selection strategies. You will independently perform tumor cell inoculations, administration of therapeutic agents via multiple routes, tumor measurements, survival and overall animal health monitoring, tissue collection, and data recording. The laboratory responsibilities will occupy approximately 50% of your time and include ex vivo immune cell analyses and/or PK/PD biomarker analyses and offer opportunity for professional growth and learning.  We are #BrighterTogether 

 

How you will spend your day:

  • As a member of drug discovery cross-functional teams, you will provide technical support for I-O target validation and biomarker discovery studies. Set-up and validate new ex vivo and in vivo disease models, and cell-based assays within a project scope
  • Executing in vitro and ex vivo cell-based immunoassays to characterize the mechanism of action and activity of small molecule drugs designed to enhance anti-tumor immunity
  • Conducting exploratory and pre-clinical PK, PD and efficacy studies
  • Sub-cutaneous tumor cell inoculation and iv infusion of primary cells
  • In vivo dosing of mice via various routes (ip, iv, sc and po)
  • Tissue harvesting (blood, tumor, lymph nodes, spleen, etc.)
  • Acquiring/analyzing data, report the data and troubleshoot for problems in experiments
  • Tracking and reporting study progress and status with oversight from supervisor and/or project leader
  • Accurate documentation and outstanding data recording

 

Key things about you:

  • Minimum 2-4 years of directly relevant lab experience in an academic or industry setting
  • Documented in vivo experimental skills
  • Experience with mouse syngeneic and xenograft tumor models, i.e., tumor cell inoculation, mouse dosing, tissue harvesting, tumor measurements
  • Proficiency in lab animal welfare and ability to precisely follow institutional procedures and protocols
  • Experience in multiparameter flow cytometry, ex vivo primary/immune cell isolation and culture; experience in working with cell lines and human tissue/blood samples
  • Prior experience with any of the following assays is preferred: ELISA, Western blot, Luminex assay
  • Strong attention to detail, excellent record keeping and organizational skills
  • Proficiency with Microsoft Office
  • Flexibility in working schedule to accommodate weekend work
  • Ability to work both independently and with multiple collaborative teams
  • Excellent communication and interpersonal skills
  • Experience with minimally invasive surgical procedures is preferred
  • Effective verbal and written communication skills
  • Proactive and collaborative approach to each day
  • Friendly to others, eager to work and generally a pleasure to be around

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Constellation Pharmaceuticals recognizes the value of diversity in our workforce. We are committed to equal opportunity. We consider all qualified employment applicants without regard to race, religion, color, gender, age, national origin, sexual orientation, gender identity, partnership status, protected veteran status, disability, or any other status protected by federal, state, or local law. Individuals who hold legal work authorization applicable to employment at Constellation Pharmaceuticals in the United States will be considered without regard to citizenship/alienage. Constellation Pharmaceuticals is a participant in E-Verify.

We are not accepting unsolicited resumes from employment agencies for any employment opportunities at this time.