Computational Biologist | Functional Genomics

The Functional Genomics group at Constellation seeks a highly motivated and enthusiastic Computational Biologist to be a part of an integrated computational/experimental biology team that identifies and validates novel oncology and immuno-oncology targets in the area of chromatin-mediated transcriptional regulation.  The ideal candidate will have a strong background in integrated NGS pipeline and data analysis, experience manipulating large genomic datasets, understanding of cancer biology, and a desire to contribute to an evolving and diverse drug discovery pipeline.  The position requires the ability to succeed in a dynamic, goal-oriented and highly collaborative environment.  We are #BrighterTogether.

 

How you will spend your day:

  • Designing, analyzing, visualizing and interpreting NGS experiments including ChIP-seq, RNA-seq, ATAC-seq, and single cell RNAseq, with the aims of generating and refining target hypotheses, identifying biomarkers, and supporting mechanism of action studies
  • Identifing, triaging, implementing and developing state-of-the-art computational method and data mining strategies to address key challenges in oncology drug discovery
  • Constructing robust and high-performance bioinformatics pipelines and make sharable toolbox available to facilitate large scale studies and cross team collaborations.
  • Collaborating with scientists to design experiments and analyses to further our drug development efforts.
  • Supporting new target identification through data mining and analyses of internal and publicly available functional screening datasets. Providing statistical support to scientists.
  • Clearly communicating and preseningt results, interpretation, and recommendations to broad scientific audiences, assist in project design and make impact on company drug development decision-making.

 

Key things about you:

  • Ph.D. with 3+ years postgraduate experience, or MS with 5+ years pharma/biotech experience.
  • Degree in computational biology/bioinformatics/statistics/genetics or other biomedical sciences with quantitative research training.
  • Expertise in one or more of the NGS experiment design and analysis: gene expression (bulk/single-cell RNA-seq), epigenetics (Chipseq and ATAC-seq), DNA sequencing (Copy Number and variant detection), and bioinformatics method development.
  • Fluent programming skills in one or more of R, Python, Perl, shell scripting or other programming languages.
  • Proficient in common bioinformatics and NGS analysis tools/packages. Experience of parallel computing and job management in high performance computing cluster or cloud computing (AWS, Azure or G Cloud) is highly desirable.
  • Experience in bioinformatics pipeline construction using workflow and version control tools is a plus.
  • Familiar with public tumor genomic databases (such as TCGA, cBioPortal and ICGC), and other public omics datasets is highly desirable.
  • Expertise in cancer biology and understanding of the principles of cancer genetics is desirable.

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Constellation Pharmaceuticals recognizes the value of diversity in our workforce. We are committed to equal opportunity. We consider all qualified employment applicants without regard to race, religion, color, gender, age, national origin, sexual orientation, gender identity, partnership status, protected veteran status, disability, or any other status protected by federal, state, or local law. Individuals who hold legal work authorization applicable to employment at Constellation Pharmaceuticals in the United States will be considered without regard to citizenship/alienage. Constellation Pharmaceuticals is a participant in E-Verify.

We are not accepting unsolicited resumes from employment agencies for any employment opportunities at this time.