Job Opportunities
At Constellation all of our employees are committed to meeting the unmet medical needs of patients. We are passionate about our work and strive for scientific breakthroughs, viewing each day as an opportunity to learn from one another. At Constellation we work hard and play hard. Whether it's a charity bike race, family fun or getting together after work, we enjoy our colleagues' company outside of the labs and meeting rooms. We believe that the key to a successful company are passionate, challenged, appreciated, and rewarded employees.
Exciting opportunities exist throughout the Company:
Senior Research Associate – Pharmacology
Responsibilities:
- Develop and run cell-based assays to support our drug discovery oncology programs and to study the mechanism of actions of our compounds
- Propose experiments, generate and evaluate data in the area of oncology. This involves protein and RNA level determination using FACS, ELISA, Western Blot and qPCR analysis
- Provide biological support to teams developing small molecules in the field of oncology
Qualifications:
- BS/MS or equivalent, with a minimum of 4 years experience in the pharmaceutical industry
- Proficiency in cell culture, cell assays including FACS and phenotypic assays, cellular and molecular methods, including qPCR, ELISA, and western blot
- Experience in drug discovery, and cancer biology
- Very organized, good at tracking and organizing data
- Team-player, comfortable working in a matrix environment on multiple projects
- Flexible and enthusiastic with strong communication skills
Job Code SRAP – EN
Senior level Scientist – Medicinal Chemistry (title commensurate with experience)
Responsibilities:
- Focused work on the design of novel chemical entities
- Identify structure activity relationships (SAR) to address lead optimization, potency, selectivity, pharmacokinetics and in vivo efficacy
- Extensive work with structure-based drug design
- Collaborate with a broad group of scientists and interact with external collaborators
Qualifications:
- Ph.D. in synthetic organic chemistry,5-10 years of relevant experience preferably in oncology
- Biotech or large pharmaceutical experience working as a bench chemist necessary
- Experience with modern structure-based drug design
- Fragment/structure based design experience is preferred
- Proven superior laboratory skills
- Ability to work independently and interact with a multidisciplinary team of medicinal chemists, biologists, pharmacologists and external collaborators
- Proven track record of innovative project contributions including peer-reviewed publications/patent applications
- Project leadership skills a plus
- Excellent oral / written communication and presentation skills
- Flexibility to work in a dynamic, fast paced environment
Job Code SS-BA
Scientist – Biology
Responsibilities:
- Detailed knowledge of cutting-edge molecular, cellular and biochemical approaches, especially chromatin-relevant techniques
- Design and implement cell based RNAi screens to identify novel biological targets for cancer treatment
- Validate known and novel biological targets to determine the feasibility of these targets as potential candidate drug targets by developing biochemical and cellular assays
- Elucidate target mechanisms in the context of cancer pathways and chromatin biology
Qualifications:
- PhD, with 3-5 years of industry or post-doc experience in Cancer Biology or epigenetics
- Strong molecular and cellular biology skills
- Experience with epigenetics preferred
- Strong communication skills
- Ability to work well independently as well as part of an integrated, interdisciplinary team
Job Code – BIO-JM
Scientist – Biology
Responsibilities:
- Design and implement ChIP-chip, ChIP-seq experiments
- Assist fellow researchers in designing and implementing ChIP assays
- Design and implement cell-based RNAi screens to identify novel biological targets for cancer treatment
- Validate known and novel biological targets to determine the feasibility of these targets as potential candidate drug targets
- Perform variety of activities ranging from target validation, assay development and cell-based screens in oncology
- Elucidate target mechanisms in the context of cancer pathways and chromatin biology
Qualifications:
- PhD, with 3-5 years of industry or post-doctural experience in Cancer Biology
- Detailed knowledge of cancer signaling pathways is desired
- Extensive experience in ChIP-chip, ChIP-seq procedures
- Experience in cellular and molecular biology techniques including cell culture, transfection, immunoprecipitation, Western blotting, RT-qPCR and RNAi procedures is required.
- Strong communication skills
- Ability to work well independently as well as part of an integrated, interdisciplinary team
Job Code – BIO-MS
Scientist – Lead Discovery
Responsibilities:
- The scientist will develop, optimize, validate, and execute biochemical assays in support of small molecule drug discovery projects.
- Primary responsibilities include assay development, screening, and in-depth characterization of small molecule leads for nascent and ongoing chemistry programs.
Qualifications:
- This position requires an enzymologist/biochemist with experience in biochemical assay development, in addition to HTS screening experience.
- A B.S./M.S. degree in Biochemistry/Chemistry/Biology with 2 or more years experience in a biotech or pharmaceutical environment is required.
The following experience/qualifications are preferred:
- An enzymologist with a drug discovery background
- Experience in defining inhibition mechanisms of small molecules, and application of biophysical technologies (e.g. calorimetry, surface plasmon resonance) towards lead discovery.
Job Code – LDCB
Research Associate – Lead Discovery
Responsibilities:
- Hands-on knowledge of laboratory robotics, liquid handling and sample management
- Compound plating, routine maintenance and operation of laboratory robotics and troubleshooting process design to support drug discovery programs in highly automated environment with minimal supervision.
Qualifications:
- The preferred candidate will have experience in compound management ideally in a biotech or pharma environment.
- Additional desirable skills/experiences would include high throughput screening and the ability to troubleshoot routine equipment problems.
- Strong communication, data management, and organizational skills are required.
- A B.S./M.S. degree with 2 to 7 years industrial experience is required.
Job Code – LDTP
Constellation Pharmaceuticals is an Equal Opportunity Employer, and offers a comprehensive benefits package, including health, dental, 401(k), paid vacation, tuition reimbursement, and much more.
We are not accepting unsolicited resumes from employment agencies for any employment opportunities at this time.