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Job Opportunities

At Constellation all of our employees are committed to meeting the unmet medical needs of patients. We are passionate about our work and strive for scientific breakthroughs, viewing each day as an opportunity to learn from one another.  At Constellation we work hard and play hard. Whether it’s a charity bike race, family fun or getting together after work, we enjoy our colleagues’ company outside of the labs and meeting rooms. We believe that the key to a successful company are passionate, challenged, appreciated, and rewarded employees.

Current Openings:  

We are looking for the following full time positions to join our organization, contribute to an outstanding research, development and business team and be part of the next major product engine leveraging insights from the rapidly expanding field of chromatin biology to discover and develop small molecule therapeutics for the treatment of cancer, inflammatory/immunologic disorders and other diseases.

Research Associate– Lead Discovery

Our Lead Discovery group is seeking a RA in Compound Management. This individual will be responsible for the execution of the day to day procedures necessary to accomplish the business critical function of compound management. This includes compound plating, inventory management and utilization of laboratory robotics. This individual will be critical to daily operations as well as troubleshooting process design to support the drug discovery programs in an automated environment.



 Job Code: RA-SM

Principal Engineer/Platform Architect

As the Principal Engineer/Platform Architect, you will lead the design, implementation and growth of our information architecture. The successful leader will manage infrastructure and resources to meet organizational needs and will be responsible for working cross-functionally with all departments to identify long-term, scalable, practical solutions for research and operations as the organization grows. Projects will include (but are not limited to): selecting, implementing, extending and maintaining the company data storage and capture systems (Chem/Bio Registration, LIMS, ELN, SDMS), and data analysis systems to support pre-clinical and clinical efforts including Constellation’s high throughput screening (HTS) Platform. The individual will also be expected to grow and manage the company’s laboratory informatics infrastructure and provide informatics/engineering support as needed.


Knowledge, Skills, and Abilities:


Senior/ Principal Research Associate – Biology

Department of Biology is looking for an experienced senior level research associate to conduct oncology target validation and drug discovery project support in a highly collaborative, goal-oriented team environment. The position requires excellent hands-on experience with commonly used techniques in cancer cell biology and/or chromatin biology.


Key Skills required:


Scientist – Immuno-oncology

At Constellation Pharmaceuticals we are pushing the boundaries of our understanding of how epigenetic mechanisms control transcription in health and disease, and by so doing we are discovering novel treatments for immune-mediated diseases and cancer. We now have an exciting opportunity for an Immuno-oncology Scientist. You will be responsible for the development of mechanistic in vitro, in vivo and ex vivo assays in the context of tumor immunology/cancer immunotherapy. Your role will be to discover and validate epigenetic targets, and to characterize small molecule compounds for advancing drug discovery programs. You will be expected to conduct hands-on work and to generate and evaluate data in the area of immuno-oncology, including phenotyping, differentiation and characterization of human and murine leukocyte subsets; adoptive cell transfer, Treg suppression assays, bone marrow chimeras, FACS, cell sorting, ELISPOT, ELISA and other immunologically-relevant techniques.

You will provide immuno-oncology representation in drug discovery programs and present at both internal and external meetings, and you will have the opportunity to publish work in peer-reviewed journals.



Head of Medicinal Chemistry

Constellation Pharmaceuticals is the leading company that seeks to translate our fundamental expertise in chromatin biology into important small molecule therapeutics for patients in need.  We are looking for an accomplished, highly motivated and creative medicinal chemist to join our multidisciplinary team as we grow this essential function.

The Candidate will:



Research Associate / Senior Research Associate, Immuno-oncology

We are adding to the team and now have an exciting opportunity for an Immuno-Oncology Research Associate. You will support the development of mechanistic in vitro, in vivo and ex vivo immunological assays and cellular analyses. You will contribute to the discovery and validation of epigenetic targets, and to the characterization of small molecule compounds in the context of drug discovery programs. As an RA you will be expected to conduct hands-on laboratory work and to generate and evaluate data in the area of tumor immunology and cancer immunotherapy, according to the following job requirements:



Constellation Pharmaceuticals is an Equal Opportunity Employer, a participant in E-Verify and offers a comprehensive benefits package, including health, dental, 401(k), paid vacation, tuition reimbursement, and much more.

We are not accepting unsolicited resumes from employment agencies for any employment opportunities at this time.