Epigenetics Discoveries
Major Discoveries
Illuminate Potential of Field
Timeline of Epigenetics Study
Studies that demonstrate the effect of
epigenetic factors:
1.
Goldberg, A.D., C.D. Allis, and E. Bernstein,
Epigenetics: a landscape takes shape.
Cell, 2007. 128(4): p. 635-8.
2.
Rice,
J.C. and C.D. Allis, Histone methylation versus
histone acetylation: new insights into epigenetic
regulation. Curr Opin Cell Biol, 2001. 13(3):
p. 263-73.
3.
Kimura, A., K. Matsubara, and M. Horikoshi, A decade
of histone acetylation: marking eukaryotic chromosomes
with specific codes. J Biochem (Tokyo), 2005. 138(6):
p. 647-62.
4.
Brownell, J.E., et al., Tetrahymena histone
acetyltransferase A: a homolog to yeast Gcn5p linking
histone acetylation to gene activation. Cell, 1996.
84(6): p. 843-51.
5.
Taunton, J., C.A. Hassig, and S.L. Schreiber, A mammalian
histone deacetylase related to the yeast transcriptional
regulator Rpd3p. Science, 1996. 272(5260): p.
408-11.
6.
Yoder, J.A., et al., DNA
(cytosine-5)-methyltransferases in mouse cells and
tissues. Studies with a mechanism-based probe. J Mol
Biol, 1997. 270(3): p. 385-95.
7.
Chen,
D., et al., Regulation of transcription by a protein
methyltransferase.
Science, 1999. 284(5423): p. 2174-7.
8.
Rea,
S., et al., Regulation of chromatin structure by
site-specific histone H3 methyltransferases. Nature,
2000. 406(6796): p. 593-9.
9.
Dhalluin, C., et al., Structure and ligand of a
histone acetyltransferase bromodomain.
Nature, 1999. 399(6735): p. 491-6.
10.
Jacobson, R.H., et al., Structure and function of a
human TAFII250 double bromodomain module. Science,
2000. 288(5470): p. 1422-5.
11.
Wang,
Y., et al., Human PAD4 regulates histone arginine
methylation levels via demethylimination. Science,
2004. 306(5694): p. 279-83.
12.
Cuthbert, G.L., et al., Histone deimination
antagonizes arginine methylation.
Cell, 2004. 118(5): p. 545-53.
13.
Shi,
Y., et al., Histone demethylation mediated by the
nuclear amine oxidase homolog LSD1.
Cell, 2004. 119(7): p. 941-53.
14.
Tsukada, Y., et al., Histone demethylation by a
family of JmjC domain-containing proteins.
Nature, 2006. 439(7078): p. 811-6.
15.
Whetstine JR. et al., Reversal of histone lysine
trimethylation by the JMJD2 family of histone
demethylases. Cell, 2006, 205(3): p. 467-81.
16.
Sims,
R.J., 3rd, et al., Recognition of trimethylated
histone H3 lysine 4 facilitates the recruitment of
transcription postinitiation factors and pre-mRNA
splicing. Mol Cell, 2007. 28(4): p. 665-76.
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