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Is there a code embedded in proteins
that is based on post-translational modifications?
Abstract
Covalent post-translational modifications (PTMs)
provide vast indexing potential and expanded protein
use. The 'histone code' hypothesis has inspired
rapid advances throughout chromatin biology, and has
recently been tapped for its relevance to non-histone
proteins. Comprehensive analyses suggest that rather
than constituting a general code, the covalent
modifications of proteins (including histones)
provide surfaces that are recognized by effectors
that can give rise to intricate interactions and
downstream events. These are reminiscent of other
regulatory cascades in transcription and cell
signalling.
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